ArcA-Regulated Glycosyltransferase Lic2B Promotes Complement Evasion and Pathogenesis of Nontypeable Haemophilus influenzae

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منابع مشابه

ArcA-regulated glycosyltransferase lic2B promotes complement evasion and pathogenesis of nontypeable Haemophilus influenzae.

Signaling mechanisms used by Haemophilus influenzae to adapt to conditions it encounters during stages of infection and pathogenesis are not well understood. The ArcAB two-component signal transduction system controls gene expression in response to respiratory conditions of growth and contributes to resistance to bactericidal effects of serum and to bloodstream infection by H. influenzae. We sh...

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ArcA - regulated glycosyltransferase Lic 2 B promotes complement evasion and 1 pathogenesis of nontypeable Haemophilus influenzae 2 3 4

3 4 Sandy M. S. Wong 1 , Frank St. Michael 3 , Andrew Cox 3 , Sanjay Ram 2 , and Brian J. Akerley 1 * 5 6 7 Department of Microbiology and Physiological Systems 1 and Division of Infectious Diseases and 8 Immunology 2 , University of Massachusetts Medical School, Worcester, MA, 01655, Institute for 9 Biological Sciences, National Research Council, Ottawa, ON Canada KIA 0R6 3 . 10 11 *Correspond...

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Nontypeable Haemophilus influenzae: pathogenesis and prevention.

In this paper, we describe the ability of nontypeable Haemophilus influenzae (NTHi) to coexist with the human host and the devastating results associated with disruption of the delicate state of balanced pathogenesis, resulting in both acute and chronic respiratory tract infections. It has been seen that the strains of NTHi causing disease show a marked genetic and phenotypic diversity but that...

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Vaccine Candidates against Nontypeable Haemophilus influenzae: a Review

Nonencapsulated, nontypeable Hemophilus influenzae (NTHi) remains an important cause of acute otitis and respiratory diseases in children and adults. NTHi bacteria are one of the major causes of respiratory tract infections, including acute otitis media, cystic fibrosis, and community-acquired pneumonia among children, especially in developing countries. The bacteria can also cause chronic dise...

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Nontypeable Haemophilus influenzae and childhood pneumonia.

Nontypeable Haemophilus influenzae (NTHi) is a common microbe frequently isolated from the nasopharynx of children. Bacterial pneumonia is a major cause of morbidity and mortality in children less than 5 years of age, with the burden of disease being greatest in developing countries. Determination of the bacterial aetiology of pneumonia is difficult due to sampling constraints. However, with a ...

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ژورنال

عنوان ژورنال: Infection and Immunity

سال: 2011

ISSN: 0019-9567,1098-5522

DOI: 10.1128/iai.01269-10